THE weight loss stumbling block
Losing weight can be quite difficult. The urge to eat sweet food can be so prevalent that you can’t resist it, no matter how hard you try. Often you think you must just lack willpower, or worse, others will tell you that you do … You feel guilty, frustrated and desperate when you keep going for sweet food even though you don’t really want it. Sound familiar?
Out of balance
Being overweight and struggling to lose weight are both symptoms of a body that is out of balance. This applies to your microbiome (intestinal flora), hormones and constitution type. If these are out of balance:
- fat is stored instead of being burned
- you don’t have enough energy to move
- your desire for sweetness and sugars is maintained
- you may be addicted to food
- don’t feel full or satisfied
- you feel depressed
- etc.
Yes, you read it correctly. A tendency towards sweetness and sugar when you are overweight is partly caused by a hormonal imbalance and other body processes that are out of balance. Not being able to resist all kinds of sweets is therefore not always due to a lack of willpower.
How about this?

It starts with …
When you are overweight, several body processes are disturbed, such as your
- metabolism
- fat metabolism
- regulation of hunger and feeling full
- cravings for (sweet) food
- mental state
A number of hormones and other messenger substances play important roles in this, such as insulin, growth hormone, estrogen, testosterone, DHEA, leptin, ghrelin, dopamine and serotonin. These messenger substances are no longer able do their job effectively if you are overweight.
This process usually starts with a permanently high blood sugar level. Many things can be affected when the supply of sugar is continuously high, including:
- Eating / drinking a lot of sugar
- Chronic stress
- Lack of sleep
- Lack of movement / excercise
- Already overweight
- etc.

Insulin
The pancreas measures the amount of sugar in your blood. When this increases, it releases insulin (sugar hormone). When the blood sugar level drops, it stops releasing insulin. Insulin ensures that sugar can get into your target cells (e.g. muscle and nerve cells) by means of the key-lock principle. Insulin uses a key to open the lock on the door of the target cell and in this way sugar enters the cell to be used as fuel or stored as a reserve. This reduces the amount of sugar in your blood.
Insulin:
- converts glucose into glycogen (storage of sugar) in liver and muscle cells
- stimulates the production of fats
- ensures the storage of fats in fat tissue
- lowers the burning of fat
- suppresses the feeling of hunger
Insulin resistance
When there is constantly too much sugar in your blood and too much insulin is produced in response, the number of ‘locks’ for insulin on the target cells decreases. This is a natural reaction of your body to the ever-increasing amount of sugar and insulin in your blood. It is a congenital protective mechanism to prevent too much sugar from getting into your cells and your blood sugar level from dropping too low.
By reducing the number of locks on the target cells, they have become ‘deaf’ to insulin, so to speak. In this way, less sugar can get into the cell. As a result, the amount of sugar in your blood remains high and your pancreas continues to release insulin in response. Subsequently, the amount of insulin in your blood remains high. We call this situation ‘insulin resistance’.
When you are overweight, insulin resistance almost always plays a role.
The consequences of insulin resistance include:
- Your muscle and brain cells become ‘deaf’ to insulin. This leads to, among other things, fatigue and a lack of energy, both physically and mentally.
- An increased desire for food, especially sweet food.
- You can’t stop eating due to a lack of inhibition
- A disturbance in many other hormonal processes and an underactive thyroid gland with all of the associated consequences.
Other messenger substance ‘resistances’
As with insulin resistance, target cells can also become ‘deaf’ to a number of other messenger substances, such as leptin, ghrelin and dopamine. It occurs in a similar way to insulin: a chronic excess of leptin, ghrelin or dopamine reduces the number of ‘locks’ on the target cells.
In the case of obesity, besides insulin resistance, leptin, ghrelin and dopamine resistance also play a role.
Leptin resistance has even more negative consequences. It also lowers your metabolism in order to save energy and fat tissue.
Unhealthy vicious circle
As a result of insulin, leptin, ghrelin and dopamine resistance, you end up in an unhealthy vicious circle. Insulin resistance maintains your feeling of hunger and makes you want to eat more. Leptin resistance results in you not getting that feeling of being full, so you keep eating and eat more than you need. In reaction to this, your blood sugar level, insulin release and leptin levels remain high. This results in even more fat cells, even more leptine release, even more “resistance” to leptine and ultimately more obesity.
Above all, do not count calories
Perhaps you believe that the solution to obesity is eating less (counting calories), dieting and exercising more. The traditional approach to losing weight is to burn more calories than you eat. This theory is outdated. Unfortunately many people, dietitians and weight loss programmes still focus solely on calorie counting.
A body that is out of balance does not recover by counting calories, eating less and exercising more. On the contrary, eating less for a longer period of time slows down your metabolism (less burning) and increases your feeling of hunger, especially the appetite for tasty treats. This is precisely why it is so difficult to maintain a strict diet.
In addition, dieting is not the solution to the various forms of ‘resistance’ either. The production of leptin decreases as a result of fasting and dieting. If you are overweight and lose fatty tissue, the amount of leptin in your blood decreases, which increases the urge to eat even more.

THE stumbling block for weight loss
The combined effect of messenger substance ‘resistances’ in the case of obesity make it quite difficult to lose weight. When your brain encourages you to eat mostly sweet and unhealthy foods, it is difficult to resist. It takes a lot of willpower to ignore this. These are stumbling blocks that are not easy to overcome.
“The combined effect of messenger substance ‘resistances’ are the stumbling block to losing weight”
Solution
Now you might be thinking that the battle against those extra kilos and being overweight is lost once you have developed the various ‘resistances’ and have entered an unhealthy vicious circle. Fortunately that is not the case! You can reverse these resistances and bring your body back into balance.
What helps us to break the vicious circle is increasing the number of ‘locks’ on the target cells for (among other things) leptin and insulin, so that they can do their job properly again. In this way you can reverse the ‘resistance’ to various hormones and other messenger substances in your body.
How can you do this? With a healthy diet, sufficient nutrients, vitamins and minerals, enough exercise, stress reduction, relaxation, sufficient sunlight and doing things that make you happy. I know, it sounds like an open door, and yet it is. There is no better way to tackle the problem than at the cause itself. The different resistances and the imbalances in all of your other body processes are caused by an unhealthy lifestyle.
Conclusion
Losing weight is therefore not as straight forward as it seems. Not being able to lose weight is not just a question of a lack of willpower. It is an imbalance in your hormones and many other body processes.
A body that is out of balance cannot lose weight. As long as this situation is maintained, losing weight is a battle you will not win.
If you want to lose weight sustainably, your body first has to get back into balance. And you do that with a healthy lifestyle.
“A body that is out of balance works against (permanent) weight loss.”
How to get started ?!
In the case of obesity, there are many more body processes that play a role than I have told you about here.
Have you become curious and do you want to know more about:
- What other factors play a role in obesity?
- What role dopamine resistance and serotonin play in obesity?
- Why stress is a guaranteed weight gainer?
- Targeted solutions to lose weight?
Then join the “If Losing Weight Fails” programme. In this 15-day programme you will gain insight into which causal factors can play a role in your body and discover what you can do to get your body back into balance.
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